SML0329

Carcinine dihydrochloride

≥98% (HPLC)

• Sinonimo/i: β-Alanylhistamine dihydrochloride, 3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide dihydrochloride, Alistin, Beta-Alanylhistamine dihydrochloride
• Formula empirica (notazione di Hill): C₈H₁₄N₄O · 2HCl
• Numero CAS: 57022-38-5
• Peso molecolare: 255.14
• Numero MDL: MFCD22200567
• Codice UNSPSC: 12352200
• ID PubChem: 329825334
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: H₂O: >15 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl.Cl.NCCC(=O)NCCc1cnc[nH]1
• InChI: 1S/C8H14N4O.2ClH/c9-3-1-8(13)11-4-2-7-5-10-6-12-7;;/h5-6H,1-4,9H2,(H,10,12)(H,11,13);2*1H; ZQTUNIWBUQUKAM-UHFFFAOYSA-N

Descrizione

Descrizione generale

Carcinine, a natural peptide derivative, with a β-alanyl residue and a histamine, carries an imidazole ring. In mammals, carcinine is present in the brain, muscle, intestine and liver tissues.

Applicazioni

Carcinine dihydrochloride has been used to study its effects on dopaminergic neuron degeneration.

Azioni biochim/fisiol

Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.

Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity.

Carcinine is a selective histamine H3 antagonist; antioxidant.

Caratteristiche e vantaggi

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H318,H335
• Consigli di prudenza: P280 - P302 + P352 - P305 + P351 + P338 + P310
• Classi di pericolo: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable