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SML0276

Sigma-Aldrich

BD 1063 dihydrochloride

≥98% (HPLC)

Sinonimo/i:

1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride, BD1063 dihydrochloride

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About This Item

Formula empirica (notazione di Hill):
C13H18Cl2N2 · 2HCl
Numero CAS:
206996-13-6
Peso molecolare:
346.12
Numero MDL:
MFCD00792740
Codice UNSPSC:
12352200
ID PubChem:
329825284
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

white to beige

Solubilità

H2O: >15 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

Cl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2

InChI

1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
NXFDBTLQOARIMH-UHFFFAOYSA-N

Applicazioni

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:
  • to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
  • in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
  • to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

Azioni biochim/fisiol

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

Altre note

air sensitive

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
046M4712V
052M4706V

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Mojtaba Keshavarz et al.
Advanced pharmaceutical bulletin, 10(3), 452-457 (2020-07-16)
Purpose: Memantine is an approved drug for the treatment of Alzheimer's disease (AD). Autophagy, lysosome dysfunction, and sigma receptors
Tao Bai et al.
Journal of cellular and molecular medicine, 23(11), 7349-7359 (2019-09-12)
Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Sorafenib is a strong inducer of ferroptosis but not of apoptosis. However, the mechanism of sorafenib-induced
Conor C Smith et al.
Molecular pharmacology, 86(4), 390-398 (2014-07-25)
Fast excitatory synaptic transmission that is contingent upon N-methyl d-aspartate receptor (NMDAR) function contributes to core information flow in the central nervous system and to the plasticity of neural circuits that underlie cognition. Hypoactivity of excitatory NMDAR-mediated neurotransmission is hypothesized
Michael A Wheeler et al.
Cell, 176(3), 581-596 (2019-01-22)
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational

Articoli

Sigma Receptors

Sigma receptors may constitute favorable targets for drug design in conditions such as psychiatric and movement disorders, amnesia, depression, cancer, inflammation and cocaine addiction.

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