SML0025

Safinamide mesylate salt

≥98% (HPLC)

• Sinonimo/i: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;
• Formula empirica (notazione di Hill): C₁₇H₁₉FN₂O₂ · xCH₄O₃S
• Numero CAS: 202825-46-5
• Peso molecolare: 302.34 (free base basis)
• Numero MDL: MFCD15145475
• Codice UNSPSC: 12352200
• ID PubChem: 329825096
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Attività ottica: [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
• Colore: white to tan
• Solubilità: H₂O: ≥15 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
• InChI: 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1; YKOCHIUQOBQIAC-YDALLXLXSA-N
• Informazioni sul gene: human ... MAOB(4129)

Descrizione

Applicazioni

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).

Safinamide mesylate salt may be used in cell signaling studies.

Azioni biochim/fisiol

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

Caratteristiche e vantaggi

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319,H361d
• Consigli di prudenza: P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable