SAB5701928

Anti-Phospho-MLKL-S454 antibody produced in rabbit

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: liquid
• Reattività contro le specie: human, mouse
• Concentrazione: 0.464 mg/mL
• tecniche: western blot: 1:500-1:2000
• N° accesso UniProt: Q8NB16
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pSer454)
• Informazioni sul gene: human ... Phospho-MLKL-S454(197259)

Descrizione

Descrizione generale

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Immunogeno

A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.

Stato fisico

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable