SAB5701781

Anti-Phospho-CSF1R-Y708 antibody produced in rabbit

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: liquid
• Reattività contro le specie: mouse, human, rat
• Concentrazione: 2.1 mg/mL
• tecniche: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• N° accesso UniProt: P07333
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pTyr708)
• Informazioni sul gene: human ... CSF1R(1436)

Descrizione

Descrizione generale

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.

Immunogeno

A synthetic phosphorylated peptide around Y708 of human CSF1R (NP_005202.2).

Stato fisico

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable