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Key Documents

SAB4700632

Sigma-Aldrich

Monoclonal Anti-HLA Class I antibody produced in mouse

clone MEM-81, purified immunoglobulin, buffered aqueous solution

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

MEM-81, monoclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Concentrazione

1 mg/mL

tecniche

flow cytometry: suitable

Isotipo

IgG1

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

Descrizione generale

Human leukocyte antigen A classical class I family consists of three members including HLA-A, HLA-B and HLA-C. Members of classical class I major histocompatibility complex (MHC) contain a peptide bound to a transmembrane glycoprotein subunit, the heavy chain, in association with a soluble light chain called β2-microglobulin. Class I MHC are present in changeable volumes on all nucleated cells.
The antibody MEM-81 reacts with human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types.

The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.

Immunogeno

Leukocytes of a patient suffering with LGL type leukemia

Applicazioni

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Azioni biochim/fisiol

Human leukocyte antigen A class I downregulation is implicated in tumor invasion and development. Genetic variations in the class I major histocompatibility complex (MHC) is associated with the development of melanoma. HLA-viral peptide interaction plays a major role in the regulation of human immunodeficiency virus (HIV) infection.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter RD
Immunogenetics, 21, 235-246 (1985)
Implications for immunosurveillance of altered HLA class I phenotypes in human tumours.
Garrido F
Immunology Today, 18, 89-95 (1997)
The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
Pereyra F
Science, 330, 1551-1557 (2010)
Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinial relevance
Ferrone S and Marincola FM
Immunology Today, 16, 487-494 (1995)
Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis.
Borrego F
The Journal of Experimental Medicine, 187, 813-818 (1998)

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