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Documenti fondamentali

SAB4504031

Sigma-Aldrich

Anti-phospho-IRF-3 (pSer396) antibody produced in rabbit

affinity isolated antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 47 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

phosphorylation (pSer396)

Informazioni sul gene

human ... IRF3(3661)

Descrizione generale

IRF3 (interferon regulatory factor 3) is a transcription factor belonging to the IRF family and is involved in the innate immunity response against viruses and bacteria. The gene encoding IRF3 is localized on human chromosome 19q13.33.

Immunogeno

The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser396.

Immunogen Range: 362-411

Applicazioni

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Azioni biochim/fisiol

Activated IRF3 (interferon regulatory factor 3) influences the expression of type I interferons via the toll-like receptor (TLR3/4)-mediated signaling pathway. IRF3 can suppress glioma invasion, proliferation and migration. Studies have suggested that IRF3 may have characteristics of tumor suppression.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Genetic susceptibility in cervical cancer: From bench to bedside
Afsane Bahrami
Journal of Cellular Physiology (2017)
Interferon regulatory factor 3 in adaptive immune responses.-Laure Ysebrant de Lendonck
Laure Ysebrant de Lendonck
Cellular and Molecular Life Sciences (2014)
Interferon regulatory factor 3 alters glioma inflammatory and invasive properties
Leonid Tarassishin
Journal of Neuro-Oncology, 113 (2013)
Nikhil Jain et al.
Nature materials, 17(12), 1134-1144 (2018-10-24)
Macrophages respond to chemical/metabolic and physical stimuli, but their effects cannot be readily decoupled in vivo during pro-inflammatory activation. Here, we show that preventing macrophage spreading by spatial confinement, as imposed by micropatterning, microporous substrates or cell crowding, suppresses late
Raquel Rodrigues-Diez et al.
Scientific reports, 6, 27915-27915 (2016-06-15)
The introduction of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus greatly reduced the rate of allograft rejection, although their chronic use is marred by a range of side effects, among them vascular toxicity. In transplant patients, it is proved that

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