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Key Documents

SAB4503999

Sigma-Aldrich

Anti-phospho-TIE2 (pTyr1108) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-CD202B, Anti-GLC3E, Anti-TIE-2, Anti-VMCM, Anti-VMCM1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 125 kDa

Reattività contro le specie

mouse, rat, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

phosphorylation (pTyr1108)

Informazioni sul gene

human ... TEK(7010)

Descrizione generale

The TIE2 (TEK receptor tyrosine kinase) is also termed as TEK (tyrosine-protein kinase receptor). This gene is located on human chromosome 9p21.2. It is expressed in the Schlemm′s canal endothelial of the eye. TIE2 belongs to the receptor tyrosine kinases family.

Immunogeno

The antiserum was produced against synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108.

Immunogen Range: 1074-1123

Azioni biochim/fisiol

Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. This gene is necessary for Schlemm′s canal formation. This gene regulates vascular homeostasis by involving in auto or transphosphorylation. Tie-2 is essential for the growth of vascular structures during embryogenesis.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
Suri C, et al.
Cell, 87(7), 1171-1180 (1996)
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
Davis S, et al.
Cell, 87(7), 1161-1169 (1996)
TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation
Hossain MB, et al.
Molecular and Cellular Biology (2017)
Angiopoietin-2 and soluble Tie-2 receptor plasma levels in children with obstructive sleep apnea and obesity.
Gozal D
Obesity (Silver Spring, Md.), 25(6), 1083-1090 (2017)
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
Souma T
The Journal of Clinical Investigation, 126(7), 2575-2587 (2016)

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