SAB4503250

Anti-CAMK2 antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: CAMK2A, CaM-kinase II α chain, CaMK-II α subunit, CaMKII-α, Calcium/calmodulin-dependent protein kinase type II α chain
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 54 kDa
• Reattività contro le specie: rat, mouse, human
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• N° accesso NCBI: Q9UQM7
• N° accesso UniProt: Q13557
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CAMK2A(815)

Descrizione

Descrizione generale

Anti-CAMK2 Antibody detects endogenous levels of total CAMK2 protein.

Calcium/calmodulin dependent protein kinase II α (CAMK2) is a calcium-activated serine/threonine kinase. The gene is located on human chromosome 5q32. CAMK2 is mainly expressed in the central nervous system. It consists of a kinase domain, a regulatory domain and an association domain.

Immunogeno

The antiserum was produced against synthesized peptide derived from human CaMK2 alpha/delta.

Immunogen Range: 256-305

Azioni biochim/fisiol

Calcium/calmodulin dependent protein kinase II α (CAMK2) is essential for long-term potentiation (LTP) and spatial memory. It regulates synaptic plasticity. Dysfunction in this gene is associated with schizophrenia, epilepsy and autism spectrum disorders.

Calmodulin dependent protein kinase II complex δ (CAMK2D) modulates the functions of ion channels and Ca²⁺ handling proteins. It also regulates the phosphorylation and acetylation of histones. It has been shown to be overexpressed in the myocardium of diabetic patients.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable