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SAB4502580

Sigma-Aldrich

Anti-Retinoic Acid Receptor α antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

NR1B1, Nuclear receptor subfamily 1 group B member 1, RAR-α, RARA, Retinoic acid receptor α

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About This Item

Numero MDL:
MFCD00802878
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 50 kDa

Reattività contro le specie

human, mouse, rat

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
western blot: 1:500-1:1000

N° accesso NCBI

P10276

N° accesso UniProt

P10276

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... RARA(5914)

Descrizione generale

Anti-Retinoic Acid Receptor α Antibody detects endogenous levels of total Retinoic Acid Receptor α protein.
Retinoic acid receptor α (RARα) is a nuclear receptor for retinoic acid and is expressed in the retina. It belongs to the nuclear steroid/thyroid hormone receptor superfamily. The gene encoding it is localized on human chromosome 17q21.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor alpha.

Immunogen Range: 46-95

Azioni biochim/fisiol

Retinoic acid receptor α (RARα) is a ligand-dependent transcriptional modulator of genes that has a role in differentiation, cellular development and apoptosis. It has a role in germ-cell development in testis. The protein may be associated with acute promyelocytic leukemia.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures.
Doi A
Molecular Oncology, 9(2), 355-364 (2015)
Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
Santos NC and Kim KH
Endocrinology, 151(5), 2361-2372 (2010)
The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures.
Veerappan S
Molecular Vision, 15, 1390-1397 (2009)
NLS-RARa promotes proliferation and inhibits differentiation in HL-60 cells.
Hu XX
International Journal of Medical Sciences, 11(3), 247-254 (2014)
Kohichi Kawahara et al.
Journal of Alzheimer's disease : JAD, 42(2), 587-605 (2014-06-12)
Alzheimer's disease (AD) is a neurodegenerative process involving amyloid-β (Aβ) peptide deposition, neuroinflammation, and progressive memory loss. Here, we evaluated whether oral administration of retinoic acid receptor (RAR)α,β agonist Am80 (tamibarotene) or specific retinoid X receptor (RXR) pan agonist HX630

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