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Key Documents

SAB4500900

Sigma-Aldrich

Anti-LMTK2 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Apoptosis-associated tyrosine kinase 2, Brain-enriched kinase, Kinase/phosphatase/inhibitor 2, Lemur tyrosine kinase 2, Serine/threonine protein kinase KPI-2

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 164 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... LMTK2(22853)

Descrizione generale

Anti-LMTK2 antibody detects endogenous levels of total LMTK2 protein.
Lemur tyrosine kinase 2 (LMTK2) is a serine/threonine kinase, located in endosomal compartments. It is also termed as BREK (brain-enriched kinase), AATYK-2 (apoptosis-associated tyrosine kinase 2), cdk5, KPI-2 and Cprk. It is expressed at high levels in the plasma membrane. LMTK2 consists of 1503 amino acids and is located on human chromosome 7q21.

Immunogeno

The antiserum was produced against synthesized peptide derived from human LMTK2.

Immunogen Range: 651-700

Applicazioni

Anti-LMTK2 antibody has been used in western blotting.

Azioni biochim/fisiol

Lemur tyrosine kinase 2 (LMTK2) participates in endosomal membrane trafficking and neuronal physiology. It also participates in the differentiation of tissues and acts as a negative regulator of nerve growth factor (NGF)-induced neuronal differentiation.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?
Wiklund F
Genome Medicine, 2(7), 45-45 (2010)
Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection
Nixon A, et al.
American Journal of Physiology. Cell Physiology, 304(2), C164-C164 (2013)
Daniel F Cruz et al.
Frontiers in oncology, 11, 596861-596861 (2021-04-06)
Lemur tyrosine kinase 2 (LMTK2) is a transmembrane Ser/Thr kinase whose role has been increasingly recognized; however, when compared to other kinases, understanding of the LMTK2 networks and biological functions is still limited. Recent data have shown that transforming growth
Signal dependent ER export of lemur tyrosine kinase 2
Butler EC and Bradbury NA
BMC Cell Biology, 16(1), 26-26 (2015)
Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members
Conti A, et al.
Cancer Letters, 389, 59-69 (2017)

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