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Documenti fondamentali

SAB4300702

Sigma-Aldrich

Anti-TrkB (Ab-705) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-BDNF/NT-3 growth factors receptor precursor, Anti-GP145-TrkB, Anti-GP145-TrkB/GP95-TrkB, Anti-NTRK2, Anti-Trk-B

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

~145 kDa

Reattività contro le specie

mouse, rat, human

Concentrazione

1 mg/mL

tecniche

western blot: 1:500-1:1000

Isotipo

IgG

Sequenza immunogenica

(T-D-Y -Y-R)

N° accesso NCBI

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TrkB(4915)

Descrizione generale

The antibody detects endogenous levels of total TrkB protein.

Immunogeno

Peptide sequence around aa. 703-707 (T-D-Y -Y-R), according to the protein NP_001007098.1

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrizione del bersaglio

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Drug design, development and therapy, 13, 2513-2532 (2019-08-24)
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Jia Zhao et al.
Journal of the neurological sciences, 344(1-2), 20-26 (2014-06-24)
FK506 has been shown to exert neurotrophic and neuroprotective effects, but its long-term application for nerve regeneration is limited. This study evaluated the potential application of a novel FK506-loaded chitosan conduit for peripheral nerve repair, and explored the underlying mechanism.
Yoelvis García-Mesa et al.
Psychoneuroendocrinology, 45, 154-166 (2014-05-23)
Postmenopausal women may be more vulnerable to cognitive loss and Alzheimer's disease (AD) than premenopausal women because of their deficiency in estrogens, in addition to their usually older age. Aerobic physical exercise has been proposed as a therapeutic approach for
Rachel A Hill et al.
Biochimica et biophysica acta, 1842(11), 2126-2135 (2014-08-28)
Altered brain-derived neurotrophic factor (BDNF) signalling and dopaminergic neurotransmission have been shown in the forebrain in schizophrenia. The 'two hit' hypothesis proposes that two major disruptions during development are involved in the pathophysiology of this illness. We therefore used a
Jian Xin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7302-7313 (2014-05-23)
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB), play a critical role in memory extinction. However, the detailed role of BDNF in memory extinction on the basis of neural circuit has not been fully understood. Here

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