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Merck
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Documenti fondamentali

SAB4300525

Sigma-Aldrich

Anti-GAP43 (Ab-41) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-B-50 antibody produced in rabbit, Anti-PP46 antibody produced in rabbit, Anti-growth associated protein 43 antibody produced in rabbit

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About This Item

Numero MDL:
MFCD00164594
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

~43 kDa

Reattività contro le specie

rat, human, mouse

Concentrazione

1 mg/mL

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotipo

IgG

Sequenza immunogenica

(Q-A-S-F-R)

N° accesso NCBI

NP_001123536.1

N° accesso UniProt

P17677

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GAP43(2596)

Descrizione generale

Growth associated protein-43 (GAP-43) is a phosphoprotein associated with membrane. It is located on chromosome 3q13. During neural development and axonal regeneration, GAP43 is upregulated in neuronal growth cones and Schwann cell precursors.

Immunogeno

Peptide sequence around aa. 38-43 (Q-A-S-F-R), according to the protein GAP43.

Azioni biochim/fisiol

Growth associated protein-43 (GAP-43) participates in neurite outgrowth, growth cone navigation, neurotransmission, stabilization of axonal branches and synaptic plasticity. In humans and mice, GAP43 is recognized as a possible gene for autism and autistic-like disorders.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrizione del bersaglio

GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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A rare 3q13.31 microdeletion including GAP43 and LSAMP genes
Gimelli S, et al.
Molecular Cytogenetics, 6(1), 52-52 (2013)
Víctor Carriel et al.
Journal of tissue engineering and regenerative medicine, 11(2), 553-563 (2014-08-02)
Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used
Wei-Shen Chen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(2), 184-193 (2013-07-28)
The malignant peripheral nerve sheath tumor is a relatively uncommon type of soft tissue sarcoma arising from a peripheral nerve or extraneural soft tissues and showing nerve sheath differentiation. The diagnosis of malignant peripheral nerve sheath tumor is one of
Ryan L O'Hare Doig et al.
Frontiers in molecular neuroscience, 13, 85-85 (2020-07-17)
Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to inhibit voltage-gated Ca2+
Nuttapong Yawoot et al.
Journal of cellular physiology, 237(3), 1818-1832 (2021-11-27)
Even though astrocytes have been widely reported to support several brain functions, studies have emerged that they exert deleterious effects on the brain after ischemia and reperfusion (I/R) injury. The present study investigated the neuroprotective effects of melatonin on the
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