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SAB4200790

Sigma-Aldrich

Anti-Human IgG (Fc specific)-Peroxidase antibody, Mouse monoclonal

clone GG-7, purified from hybridoma cell culture

Sinonimo/i:

Anti-Human immunoglobulin G

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

mouse

Livello qualitativo

200

Coniugato

peroxidase conjugate

Forma dell’anticorpo

purified from hybridoma cell culture

Tipo di anticorpo

primary antibodies

Clone

GG-7, monoclonal

Forma fisica

lyophilized powder

Reattività contro le specie

human

tecniche

direct ELISA: 1:40,000-1:80,000 using 2.5 μg/mL human IgG1 for coating

Isotipo

IgG1

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Descrizione generale

IgGs are the most common Immunoglobulins isotype in blood, lymph fluid, cerebrospinal fluid, and peritoneal fluid and a key players in the humoral immune response. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), they consist of a variable Fab fragment (which includes the antibody recognition site), and a conserved Fc fragment. The IgG subclasses differ in their physical and chemical properties, their distribution pattern is found to be age-dependent and every subclass has a specific biological function. IgG deficiencies are often associated with various diseases.

The Fc fragment has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. A certain population of lymphocytes also possess an "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of Human IgG.

Monoclonal Anti-Human IgG (Fc specific) is specific for the Fc fragment of Human IgG and is observed with all human IgG subclasses but not with the Fab fragment of human IgG, purified light chains, human IgA or human IgM.

Immunogeno

Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads.

Applicazioni

The antibody is recommended to use in various immunological techniques, including ELISA.

Stato fisico

Supplied as a lyophilized powder

Altre note

This product is for R&D use only, not for drug, household, or other uses.

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Certificati d'analisi (COA)

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R Jefferis et al.
Annales de biologie clinique, 52(1), 57-65 (1994-01-01)
Secondary systemic immune responses are predominantly of the IgG class and passive administration of intravenous IgG, from pooled normal serum, is an effective prophylactic and/or therapeutic treatment for patients with defined immunodeficiencies. However, the proportions of each IgG subclass present
C B Reimer et al.
Hybridoma, 3(3), 263-275 (1984-01-01)
Stable clones of 31 mouse hybridomas that produce monoclonal antibodies (MAbs) against human IgG antigenic determinants were obtained. The number of hybridomas of different specificity described are: 2 anti-IgG1 Fc, 1 anti-IgG2 Fc, 1 anti-IgG2 Fd, 2 anti-IgG3 Fc, 2
C Papadea et al.
Critical reviews in clinical laboratory sciences, 27(1), 27-58 (1989-01-01)
Human IgG consists of two identical heavy (H) chains and two identical light (L) chains joined by interchain disulfide bridges. Heterogeneity in the amino acid sequences of the H and L polypeptides results in at least three types of IgG

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