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SAB4200781

Sigma-Aldrich

Anti-Haptoglobin antibody, Mouse monoclonal

clone HG-36, purified from hybridoma cell culture

Sinonimo/i:

Anti-HP, Anti-Zonulin

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

200

Forma dell’anticorpo

purified from hybridoma cell culture

Tipo di anticorpo

primary antibodies

Clone

HG-36, monoclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

antibody small pack of 25 μL

Concentrazione

~1.0 mg/mL

tecniche

ELISA: 0.2-0.4 μg/mL using 10 μg/ml human haptoglobin for coating
dot blot: suitable
immunoblotting: suitable
immunoprecipitation (IP): suitable

Isotipo

IgG1

N° accesso UniProt

P00738

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... HP(3240)

Descrizione generale

Haptoglobin, also known as HP, is a serum α2-glycoprotein that exists as a tetramer, composed of two smaller identical alpha (α) chains and two larger identical beta (β) chains. The α-chains are linked to each other by a disulfide bond and each β-chain is similarly linked to an α-chain.
Monoclonal Anti-Haptoglobin specifically recognizes the three types of human haptoglobin (types 1-1, 2-1, and 2-2) The antibody recognizes both purified and haptoglobin in human serum, and shows no crossreactivity with human IgG, transferrin, C-reactive protein, α-1-acid glycoprotein, albumin, hemoglobin, or bovine, goat and sheep serum haptoglobin.

Immunogeno

purified haptoglobin from pooled human plasma

Applicazioni

The antibody is recommended to use in various immunological techniques, including ELISA, dot blot, immunoprecipitation, and immunoblot . The antibody reacts against native and denatured (non-reduced) human haptoglobin but does not recognize the haptoglobin under reducing conditions.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.

Altre note

This product is for R&D use only, not for drug, household, or other uses.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Alessio Fasano
Physiological reviews, 91(1), 151-175 (2011-01-21)
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal
Kati Mokkala et al.
Metabolism: clinical and experimental, 69, 43-50 (2017-03-14)
Increased intestinal permeability with subsequent metabolic endotoxemia, i.e., elevated circulating levels of bacterial lipopolysaccharide, LPS, has been introduced as a novel initiator of obesity related metabolic disturbances in non-pregnant individuals. The objective was to investigate the extent to which intestinal
Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation.
B H Bowman et al.
Advances in human genetics, 12, 189-261 (1982-01-01)
S M Hossein Sadrzadeh et al.
American journal of clinical pathology, 121 Suppl, S97-104 (2004-08-10)
Haptoglobin is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron lossfollowing hemolysis. Also, by bindingfree hemoglobin, haptoglobin functions as an antioxidant. In addition, haptoglobin acts as a
C J Chen et al.
Infection and immunity, 64(12), 5008-5014 (1996-12-01)
The majority of in vitro-grown Neisseria gonorrhoeae strains were unable to use hemoglobin as the sole source of iron for growth (Hgb-), but a minor population was able to do so (Hgb+). The ability of Hgb+ gonococci to utilize hemoglobin
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