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Key Documents

SAB4200345

Sigma-Aldrich

Anti-SMAD7 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Sinonimo/i:

SMAD7 Antibody - Anti-SMAD7 antibody produced in rabbit, Smad7 Antibody, Anti-MADH7, Anti-MADH8, Anti-SMAD family member 7

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About This Item

Codice UNSPSC:
12352203
Numero Human Protein Atlas:
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~46 kDa

Reattività contro le specie

human, mouse, rat, bovine, monkey

Concentrazione

~1.0 mg/mL

tecniche

indirect immunofluorescence: 5-10 μg/mL using human A549 cells.
western blot: 2-4 μg/mL using whole extracts of HEK-293 cells over-expressing human SMAD7

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SMAD7(4092)
mouse ... Smad7(17131)
rat ... Smad7(81516)

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Descrizione generale

SMAD7 (mothers against decapentaplegic homolog 7) is a Tbx1 (T-box 1) interacting gene and is encoded by the gene mapped to human chromosome 18q21.1.

Immunogeno

peptide corresponding to an internal region of human SMAD7, conjugated to KLH. The corresponding sequence is identical in monkey, mouse, rat and bovine

Applicazioni

Anti-SMAD7 has been used in western blot analysis and immunofluorescence.

Azioni biochim/fisiol

SMAD7 (mothers against decapentaplegic homolog 7) is a modulator of TGFβ (transforming growth factorβ) signaling in immune cells which are associated with ulcerative colitis and inflammatory bowel syndrome. It plays a major role in the etiology of CRC (colorectal cancer). In addition, it also acts as a mediator of the negative feedback loop for both the TGFβ and BMP (bone morphogenetic proteins) signaling pathways. It is essential for the remodelling of pharyngeal artery and the enlargement of great vessel. In mouse, homozygous removal of Smad7 causes primarily fourth-related arch artery defects. Silencing of Smad7 in RCD (refractory coeliac disease) biopsy samples can decrease the expression of interleukin-6 and tumour necrosis factor-α. Polymorphism of this gene is associated with colorectal cancer. SMAD7 is an inhibitor of the TGFβ (transforming growth factor beta) /BMP (bone morphogenetic proteins) pathway.

Stato fisico

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Sodium tanshinone IIA sulfonate attenuates the transforming growth factor-?1-induced differentiation of atrial fibroblasts into myofibroblasts in vitro
Yang L
International Journal of Molecular Medicine, 35, 1026-1032 (2015)
Protective effect of diltiazem on myocardial ischemic rats induced by isoproterenol
<BIG>Wei Y, et al. </BIG>
Molecular Medicine Reports, 17, 495-501 (2018)
Multiple functional risk variants in a SMAD7 enhancer implicate a colorectal cancer risk haplotype.
Fortini BK
PLoS ONE, 9 (2014)
High Smad7 sustains inflammatory cytokine response in refractory coeliac disease.
Sedda S
Immunology, 150, 356-363 (2017)
Intronic polymorphisms of the SMAD7 gene in association with colorectal cancer.
Damavand B
Asian Pacific Journal of Cancer Prevention, 16, 41-44 (2015)

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