SAB2900181
Anti-FAP (AB1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
170-kDa melanoma membrane-bound gelatinase, FAP, FAP alpha, FAPA, Seprase, fibroblast activation protein, fibroblast activation protein alpha
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
Reattività contro le specie
human
tecniche
immunohistochemistry: 10-20 μg/mL
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... FAP(2191)
Categorie correlate
Descrizione generale
FAP gene is localized on human chromosome 2q24.2.
Fibroblast activation protein (FAP) is a type II transmembrane serine protease and a cell surface antigen. It is present as a homodimeric integral protein with dipeptidyl peptidase IV like fold. FAP has an α/β-hydrolase domain and an eight-bladed β-propeller domain. It is not expressed in normal tissues. The protein is only expressed by activated fibroblasts in response to pathologic situations.
Immunogeno
Synthetic 18 amino acid peptide from extracellular domain of human FAP. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Bovine (89%); Marmoset (83%).
Applicazioni
Anti-FAP (AB1) antibody produced in rabbit has been used in immunohistochemistry.
Azioni biochim/fisiol
Fibroblast activation protein (FAP) is expressed in several pathogenic sites including cancer, fibrosis, arthritis, wounding, or inflammation. FAP has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen.
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Stato fisico
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
L Wagner et al.
Clinical and experimental immunology, 184(3), 265-283 (2015-12-17)
Dipeptidyl peptidase (DPP) 4 (CD26, DPP4) is a multi-functional protein involved in T cell activation by co-stimulation via its association with adenosine deaminase (ADA), caveolin-1, CARMA-1, CD45, mannose-6-phosphate/insulin growth factor-II receptor (M6P/IGFII-R) and C-X-C motif receptor 4 (CXC-R4). The proline-specific
Xuguang Yang et al.
Cancer research, 76(14), 4124-4135 (2016-05-25)
Cancer-associated fibroblasts (CAF) are components of the tumor microenvironment whose contributions to malignant progression are not fully understood. Here, we show that the fibroblast activation protein (FAP) triggers induction of a CAF subset with an inflammatory phenotype directed by STAT3
FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3?CCL2 Signaling
Xuguang Yang
Cancer Research (2016)
Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha
Kathleen Aertgeerts
The Journal of Biological Chemistry, 280 (2005)
Ellen Puré et al.
Oncogene, 37(32), 4343-4357 (2018-05-04)
Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma. It has
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