SAB1401069
Anti-CENPB antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Coniugato:
unconjugated
application:
IF (d)
WB
WB
Clone:
polyclonal
Reattività contro le specie:
human
citations:
5
tecniche:
direct immunofluorescence: suitable
western blot: 1 μg/mL
western blot: 1 μg/mL
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
Reattività contro le specie
human
tecniche
direct immunofluorescence: suitable
western blot: 1 μg/mL
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CENPB(1059)
Categorie correlate
Descrizione generale
Centromere protein B (CENPB) is a dimeric protein, localized to the centromeric chromatin. It possesses a DNA-binding activity. The protein has a DNA-binding domain at the amino-terminal region and a dimerization domain at the carboxy-terminal region. The subunits of CENPB have a molecular weight of 80kDa. The gene encoding CENPB is localized on human chromosome 20.
Immunogeno
CENPB (AAH53847.1, 1 a.a. ~ 599 a.a) full-length human protein.
Sequence
MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYGVASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASNGWLDRFRRRHGVVSCSGVARARARNAAPRTPAAPASPAAVPSEGSGGSTTGWRAREEQPPSVAEGYASQDVFSATETSLWYDFLPDQAAGLCGGDGRPRQATQRLSVLLCANADGSEKLPPLVAGKSAKPRAGQAGLPCDYTANSKGGVTTQALAKYLKALDTRMAAESRRVLLLAGRLAAQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVKGHYRQAMLLKAMAALEGQDPSGLQLGLTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS
Sequence
MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYGVASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASNGWLDRFRRRHGVVSCSGVARARARNAAPRTPAAPASPAAVPSEGSGGSTTGWRAREEQPPSVAEGYASQDVFSATETSLWYDFLPDQAAGLCGGDGRPRQATQRLSVLLCANADGSEKLPPLVAGKSAKPRAGQAGLPCDYTANSKGGVTTQALAKYLKALDTRMAAESRRVLLLAGRLAAQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVKGHYRQAMLLKAMAALEGQDPSGLQLGLTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS
Azioni biochim/fisiol
Centromere protein B (CENPB) has a role in assembly of the components of the centromere. It binds to the 17-base pair sequence called the CENP-B box on the DNA.
Stato fisico
Solution in phosphate buffered saline, pH 7.4
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Certificati d'analisi (COA)
Lot/Batch Number
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences.
Tanaka Y, et al.
The Journal of Biological Chemistry, 280(50), 41609-41618 (2005)
HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B.
Mukai R, et al.
The Journal of General Virology, 96(Pt 1), 159-164 (2015)
Stable complex formation of CENP-B with the CENP-A nucleosome.
Fujita R, et al.
Nucleic Acids Research, 43(10), 4909-4022 (2015)
Mapping of the human centromere protein B gene (CENPB) to chromosome 20p13 by fluorescence in situ hybridization
Naohiko S, et al.
Genomics, 24(1). (1994)
Mutational spectrum of CENP-B box and a-satellite DNA on chromosome 21 in Down syndrome children.
Chen Q, et al.
Molecular Medicine Reports, 15(4), 2313-2317 (2017)
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