S2147
Monoclonal Anti-Superoxide Dismutase (SOD) antibody produced in mouse
clone SD-G6, ascites fluid
Sinonimo/i:
Anti-ALS, Anti-ALS1, Anti-HEL-S-44, Anti-IPOA, Anti-SOD, Anti-STAHP, Anti-hSod1, Anti-homodimer
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About This Item
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
ascites fluid
Tipo di anticorpo
primary antibodies
Clone
SD-G6, monoclonal
contiene
15 mM sodium azide
Reattività contro le specie
canine, human, rat
tecniche
indirect ELISA: 1:300
Isotipo
IgG1
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... SOD1(6647)
rat ... Sod1(24786)
Descrizione generale
Monoclonal Anti-Superoxide Dismutase (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Superoxide Dismutase (SOD) is a family of metalloenzymes widely distributed in both plants and animals. In mammalian tissues, three types of superoxide dismutase [Cu-Zn-SOD, Mn-SOD, extracellular (EC)-SOD] occur. Human manganese superoxide dismutase (MnSOD), isolated from liver is composed of 22 kDa subunits each containing one Mn atom, while SOD from bovine erythrocyte has a molecular weight of 32.5 kDa. Superoxide Dismutase occurs in high concentrations in brain, liver, heart, erythrocytes and kidney.
Superoxide Dismutase (SOD) or CuZn-SOD (SOD1), a cytoplasmic and mitochondrial intermembrane space protein is located on human chromosome 21q22. It belongs to superoxide dismutase multigene family.
Specificità
The antibody recognizes natural and recombinant human-Cu-Zn-SOD, human placental SOD, and human erythrocyte SOD using direct capture or competitive ELISA. Cross-reactivity has been observed with human liver and salivary gland, rat salivary gland, pheochromocytoma cell line (PC12), and dog salivary gland. No reactivity was observed with SOD from bovine erythrocytes, kidney, and liver; dog erythrocytes; Bacillus stearothermophilus; E. coli, or horseradish.
Immunogeno
recombinant human copper-zinc superoxide dismutase (Cu-Zn-SOD).
Applicazioni
Anti-Superoxide Dismutase (SOD) antibody has been used in immunohistochemistry and Cu-Zn SOD detection via ELISA.
Azioni biochim/fisiol
Superoxide Dismutase (SOD) appear to protect cells against reactive free radicals by scavenging the superoxide radicals produced by ionization radiation or through other mechanisms. SOD have been proposed as clinically useful for a wide variety of applications including prevention of oncogenesis, tumor promotion, tumor invasiveness, radiation damage, reduction of the cytotoxic and cardiotoxic effects of anticancer drugs, as a measure against the aging process and as anti-inflammatory agents.
Superoxide Dismutase (SOD) or CuZn-SOD (SOD1) mutations results in amyotrophic lateral sclerosis It acts as a mediator of the HMF (hypomagnetic field) effect.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants
Das K, et al.
Frontiers in environmental science., 2 (2014)
Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis
Johnston JA, et al.
Proceedings of the National Academy of Sciences of the USA, 97(23), 12571-12576 (2000)
Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression
Zelko IN, et al.
Free Radical Biology & Medicine, 33(3), 337-349 (2002)
J A Johnston et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(23), 12571-12576 (2000-10-26)
Deposition of aggregated protein into neurofilament-rich cytoplasmic inclusion bodies is a common cytopathological feature of neurodegenerative disease. How-or indeed whether-protein aggregation and inclusion body formation cause neurotoxicity are presently unknown. Here, we show that the capacity of superoxide dismutase (SOD)
Marcel Maier et al.
Science translational medicine, 10(470) (2018-12-07)
Mutations in the gene encoding superoxide dismutase 1 (SOD1) lead to misfolding and aggregation of SOD1 and cause familial amyotrophic lateral sclerosis (FALS). However, the implications of wild-type SOD1 misfolding in sporadic forms of ALS (SALS) remain unclear. By screening
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
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