R4033

Rosmarinic acid

≥98% (HPLC), from Rosemarinus officinalis L.

• Sinonimo/i: (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid, 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester
• Formula empirica (notazione di Hill): C₁₈H₁₆O₈
• Numero CAS: 20283-92-5
• Peso molecolare: 360.31
• Beilstein: 2227587
• Numero MDL: MFCD00017740
• Codice UNSPSC: 12352106
• ID PubChem: 329824027
• NACRES: NA.25

Proprietà

• Origine biologica: Rosemarinus officinalis L.
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: protect from light
• Colore: white to faint beige
• Punto di fusione: 171-175 °C (lit.)
• Solubilità: H₂O: 1 mg/mL, clear, colorless
• applicazioni: metabolomics; vitamins, nutraceuticals, and natural products
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
• InChI: 1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1; DOUMFZQKYFQNTF-WUTVXBCWSA-N

Descrizione

Descrizione generale

Rosmarinic acid is a naturally occurring polyphenolic compound found in plants of the Boraginaceae family and Nepetoideae subfamily. It is an ester of caffeic acid as well as 3,4-dihydroxy-phenyllactic acid.

Applicazioni

Rosmarinic acid has been used:

• to see its protective effects on the human endothelial cell line (EA.hy926) to treat diabetic atherosclerosis
• to test its effect in 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced Parkinson′s disease (PD) models on attenuating inflammatory responses and microglia activation
• to test its neuroprotective effects on dopaminergic neurons
• to test its effects on sperm motility, viability and on intracellular calcium ion concentration
• as a reference standard in capillary zone electrophoresis (CZE) method

Azioni biochim/fisiol

Rosmarinic acid (RosA) is a well-appreciated agent used in several diabetic conditions and complications such as diabetic nephropathy, diabetic neuropathy and diabetic atherosclerosis. It has also been implicated to be a neuroprotective agent for several neurological disorders such as Alzheimer′s disease, Parkinson′s disease, and epilepsy by suppressing their conditions.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable