R3375

Retinyl palmitate

Type IV, ~1,800,000 USP units/g, oil

• Sinonimo/i: Vitamin A palmitate, all−trans−Retinol palmitate
• Formula empirica (notazione di Hill): C₃₆H₆₀O₂
• Numero CAS: 79-81-2
• Peso molecolare: 524.86
• Beilstein: 1917366
• Numero CE: 201-228-5
• Numero MDL: MFCD00019414
• Codice UNSPSC: 12352205
• ID PubChem: 24899361
• NACRES: NA.79

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 100
• Tipo: Type IV
• Saggio: ≥90% (HPLC)
• Forma fisica: oil
• Attività specifica: ~1,800,000 USP units/g
• Colore: yellow to orange
• Punto di fusione: 26 °C
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
• InChI: 1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+; VYGQUTWHTHXGQB-FFHKNEKCSA-N

Descrizione

Descrizione generale

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A, respectively. The retinoids comprise a cyclohexenyl ring with a 20-carbon with double bonds in cis and trans configuration. Retinyl palmitate is a major storage form of vitamin A. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Applicazioni

Retinyl palmitate has been used as:

• a retinoid derivative to modulate expression of connexin Cx26 and Cx30 in the cochlea
• a standard in high performance liquid chromatography(HPLC)
• as a retinoid substrate in the isomerase assay of eyecup protein homogenates

Azioni biochim/fisiol

Retinoids are ligands to nuclear receptors and have antioxidant functionality. Retinyl palmitate is widely used in pharmaceutical and cosmetic applications. In sunscreen, it protects from UVB-induced DNA damage and apoptosis. Retinyl palmitate is used to treat photoaging in skincare cosmetics. Retinyl palmitate is an effective chemopreventive agent to treat lung cancer. It also regulates various biological processes including cell differentiation and proliferation.

Review: Vitamin A metabolism.

Confezionamento

Sealed ampule.

Stato fisico

Oil at room temperature

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H360D,H412
• Consigli di prudenza: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Aquatic Chronic 3 - Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): No data available
• Punto d’infiammabilità (°C): No data available
• Dispositivi di protezione individuale: Eyeshields, Gloves, type ABEK (EN14387) respirator filter