R0775
RANK/Fc Chimera from mouse
≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
Sinonimo/i:
Osteoclast differentiation receptor, ODFR, Receptor activator of NF-κB
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About This Item
Origine biologica
mouse
Livello qualitativo
Ricombinante
expressed in NSO cells
Saggio
≥95% (SDS-PAGE)
Stato
lyophilized powder
Potenza
10.12 μg/mL EC50
PM
60 kDa
Confezionamento
pkg of 1 mg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... Tnfrsf11a(21934)
Applicazioni
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-ΚB and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis.
Azioni biochim/fisiol
TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Risultati analitici
The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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N Nakagawa et al.
Biochemical and biophysical research communications, 253(2), 395-400 (1999-01-08)
Osteoclast differentiation factor (ODF) is a ligand for osteoclastogenesis-inhibitory factor/osteoprotegerin (OCIF/OPG), and mediates an essential signal for osteoclastogenesis. Soluble-form ODF binds directly to osteoclast progenitors, suggesting the presence of a membrane-bound receptor for ODF (ODFR) on the cells. To understand
D M Anderson et al.
Nature, 390(6656), 175-179 (1997-11-21)
Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues. By capturing, processing and presenting antigens to T cells, dendritic cells are essential for immune surveillance and the regulation of specific immunity. Several members of
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