PZ0374

PF-06446846 hydrochloride

≥98% (HPLC)

• Sinonimo/i: N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
• Formula empirica (notazione di Hill): C₂₂H₂₀ClN₇O · xHCl
• Numero CAS: 1632250-50-0
• Peso molecolare: 433.89 (free base basis)
• Codice UNSPSC: 41121800
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Attività ottica: [α]/D -60 to -50°, c = 1 in methanol
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: H₂O: 2 mg/mL, clear
• Temperatura di conservazione: room temp
• Stringa SMILE: O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5
• InChI: 1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1

Descrizione

Azioni biochim/fisiol

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3