PRS4877
Anti-IL-17 (ab1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
Anti-CTLA8, Anti-Interleukin 17A
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
predicted mol wt 17 kDa
Reattività contro le specie
mouse, human
tecniche
indirect ELISA: suitable
western blot: suitable
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... IL17A(3605)
Categorie correlate
Descrizione generale
IL-17A (interleukin 17A) is a proinflammatory cytokine of Th17 (helper T cells). It is located on chromosome 6p12.
Immunogeno
a 16 amino acid peptide from near the amino-terminus of human IL-17A.
Applicazioni
Anti-IL-17 has been used in western blotting and immunohistochemistry.
Azioni biochim/fisiol
IL-17A (interleukin 17A) plays a major role in the pathogenesis of autoimmune diseases like multiple sclerosis and rheumatoid arthritis. It also plays a pathogenic role in allergic rhinitis (AR). It helps in the formation of several chemokines and cytokines in airway epithelial cells.
Linkage
The action of this antibody can be blocked using blocking peptide SBP4877.
Stato fisico
Solution in phosphate buffered saline containing 0.02% sodium azide
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection
Tsai HC, et al.
Clinical & Developmental Immunology (2013)
Nicola Tamassia et al.
European journal of clinical investigation, 48 Suppl 2, e12952-e12952 (2018-05-18)
Polymorphonuclear neutrophils are the most numerous leucocytes present in human blood, and function as crucial players in innate immune responses. Neutrophils are indispensable for the defence towards microbes, as they effectively counter them by releasing toxic enzymes, by synthetizing reactive
Jie Yang et al.
Molecular medicine reports, 20(6), 4993-5001 (2019-10-23)
Interleukin (IL)‑1β serves a crucial role in the progression of rheumatoid arthritis. Previous studies have indicated that the ERK/STAT1 signaling pathway may be involved in the inflammatory response in synovial fluid‑derived fibroblast‑like synoviocytes (sfd‑FLSs). However, the molecular mechanisms underlying the pathological
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
Ichiyama K, et al.
The Journal of Biological Chemistry, 283(25), 17003-17008 (2008)
Nicola Tamassia et al.
Frontiers in immunology, 9, 795-795 (2018-05-03)
Neutrophils are known to perform a series of effector functions that are crucial for the innate and adaptive responses, including the synthesis and secretion of a variety of cytokines. In light of the controversial data in the literature, the main
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