PRS4059

Anti-PDL-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-B7-H1, Anti-CD274 molecule, Anti-Cardif, Anti-IPS-1, Anti-Programmed cell death 1 ligand-1
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: predicted mol wt 32 kDa
• Reattività contro le specie: human, rat, mouse
• tecniche: flow cytometry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• N° accesso UniProt: Q9NZQ7
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CD274(29126)

Descrizione

Descrizione generale

PDL-1 (programmed cell death 1 ligand 1) is a cell surface protein, that is also known as B7-H1 (B7 homolog 1), coded by CD274 (cluster of differentiation 274) gene. It is located on chromosome 9p24.1. It is present on placental cells, vascular endothelial cells, liver cells, epithelial cells, mesenchymal stem cells, B cells, T cells, dendritic cells and macrophages. It is also expressed in various tumor types like melanoma, glioblastoma, cancers in the lung, kidney, head, neck, stomach, colon, pancreas, breast, cervix and ovary.

Immunogeno

17 amino acid peptide from near the center of human PDL-1.

Azioni biochim/fisiol

PDL-1 (programmed cell death 1 ligand 1) helps to clear sudden HPV (human papilloma virus) infections. It prevents the multiplication and adherence of T-cell and production of cytokine. It also controls the activities of T-cells in peripheral tissues.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4059.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable