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Merck
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Key Documents

PRS3331

Sigma-Aldrich

Anti-XIAP antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-X-linked inhibitor of apoptosis

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About This Item

Numero MDL:
MFCD01633419
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

predicted mol wt 55 kDa

Reattività contro le specie

mouse, human

tecniche

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

N° accesso UniProt

P98170

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... XIAP(331)

Descrizione generale

XIAP (X-linked inhibitor of apoptosis protein) belongs to the inhibitor of apoptosis (IAP) family. It is located on chromosome Xq25.

Immunogeno

a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.

Applicazioni

Anti-XIAP has been used in immunohistochemistry {16,17}.

Azioni biochim/fisiol

XIAP (X-linked inhibitor of apoptosis protein) modulates several cellular processes like TGF-β (transforming growth factor β) signaling, NF-κB (nuclear factor-κB) pathway, autophagy and inflammatory responses. XIAP mutations are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2).

Linkage

The action of this antibody can be blocked using blocking peptide SBP3331.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress
Riley A, et al.
Nucleic Acids Research, 38(14), 4665-4674 (2010)
Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury
Reigada D, et al.
Neuroscience, 300, 404-417 (2015)
Chao Chen et al.
Oncology letters, 15(1), 821-832 (2018-02-07)
The X-linked inhibitor of apoptosis protein (XIAP) is the best characterized member of the IAP family and is a potent inhibitor of the caspase/apoptosis pathway. It has also been revealed that XIAP has additional biological functions that rely on its
Zhuan Zhou et al.
EBioMedicine, 15, 48-61 (2017-01-04)
The emerging regulatory role of deubiquitinases (DUBs) has been implicated in various fundamental processes and pathogenesis. To determine the pivotal role that DUBs play in mediating tumorigenesis, we have performed a non-biased screen of 67 human DUBs based on a
Yiping Zhang et al.
OncoTargets and therapy, 11, 8751-8759 (2018-12-26)
Carboplatin is a first-line treatment for ovarian cancer. However, most patients develop resistance and undergo disease recurrence. This study aims to explore the relationship between the expression of X-linked inhibitor of apoptosis protein (XIAP) and carboplatin sensitivity in ovarian cancer.
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