PRS2397

Anti-BCMA antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-Tumor necrosis factor receptor superfamily, member 17
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: predicted mol wt 20 kDa
• Reattività contro le specie: human
• tecniche: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• N° accesso UniProt: Q02223
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TNFRSF17(608)

Descrizione

Descrizione generale

B-cell maturation antigen (BCMA), commonly known as TNFRSF17 (tumor necrosis factor receptor superfamily member 17), is an N-glycosylated membrane glycoprotein. It is predominantly expressed on the surface of plasma cells, and is also expressed on certain cancers such as, glioblastoma, chronic lymphocytic leukemia, Hodgkin′s lymphoma and multiple myeloma.

Immunogeno

a synthetic peptide mapping at the carboxy-terminus of human BCMA.

Azioni biochim/fisiol

TNFRSF17 (tumor necrosis factor receptor superfamily member 17) is essential for the maintenance of the survival of long-lived plasma cells in bone marrow. Its expression in peripheral blood B-cells is induced by cytokines. It gets activated by a proliferation-inducing ligand (APRIL) or B-cell–activating factor (BAFF), and gets trimerized to activate MAPK (mitogen activated kinases) and anti-apoptotic proteins. It is an appropriate target for T-cells expressing chimeric antigen receptor (CAR), and is a promising candidate for adoptive T-cell therapy of multiple myeloma. This protein is directly cleaved and shed by γ-secretase enzyme, and this is linked with level of plasma cells in bone marrow. Thus, shedding of TNFRSF17 is a candidate biomarker for B-cell involvement in autoimmune diseases. This protein is thought to be a major contributor of spinal cord-injury induced autoimmunity.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2397.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable