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P9107

Sigma-Aldrich

Anti-Potassium Channel Kv1.3 (Charybdotoxin-Sensitive Voltage-Dependent Potassium Channel, HLK3) antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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About This Item

Numero MDL:
MFCD02097210
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

lyophilized powder

Reattività contro le specie

rat, mouse, human

tecniche

immunocytochemistry: 1:50 using cells permeabilized with 0.2% Triton X-100
western blot (chemiluminescent): 1:100

N° accesso UniProt

P22001

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)

Specificità

Recognizes a full-length Kv1.3 protein. Does not cross-react with other potassium channel antigens.

Immunogeno

highly purified GST fusion protein from the C-terminal of human potassium channel Kv1.3. The protein corresponds to amino acids 471-523.

Applicazioni

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Stato fisico

Lyophilized at ~1 mg/ml from phosphate buffered saline, pH 7.4, containing 5% sucrose, 1% bovine serum albumin, and 0.025% sodium azide.

Nota sulla preparazione

Protein A purified.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Y C Cai et al.
DNA and cell biology, 11(2), 163-172 (1992-03-01)
Voltage-gated potassium channels play important functional roles in the development and maintenance of human lymphocyte functions. One such channel, known as the type n channel, has been well defined in human T cells and exhibits unique functional properties that distinguish
B Attali et al.
The Journal of biological chemistry, 267(12), 8650-8657 (1992-04-25)
Low stringency screening of a Jurkat cDNA library with a rat brain K+ channel (RCK1) probe has resulted in the isolation of HLK3, a voltage-gated K+ channel. In Xenopus oocytes, the HLK3 clone directs the expression of a rapidly activating
Stella A Nicolaou et al.
Journal of immunology (Baltimore, Md. : 1950), 183(10), 6296-6302 (2009-10-21)
The immunological synapse (IS), a highly organized structure that forms at the point of contact between a T cell and an APC, is essential for the proper development of signaling events, including the Ca(2+) response. Kv1.3 channels control Ca(2+) homeostasis
Yi-Je Chen et al.
PloS one, 8(11), e81006-e81006 (2013-12-07)
Allograft vasculopathy (AV) remains one of the major challenges to the long-term functioning of solid organ transplants. Although its exact pathogenesis remains unclear, AV is characterized by both fibromuscular proliferation and infiltration of CD4(+) memory T cells. We here tested

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