P7937
Protein Phosphatase-1 Catalytic Subunit, α-Isoform from rabbit
5,000-15,000 units/mg protein, recombinant, expressed in E. coli, lyophilized powder
Sinonimo/i:
Protein phosphatase
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About This Item
Numero MDL:
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
≥80% (GE)
Forma fisica
lyophilized powder
Attività specifica
5,000-15,000 units/mg protein
PM
37.5 kDa
tecniche
inhibition assay: suitable
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
rabbit ... PPP1CA(100009298)
Descrizione generale
Protein phosphatase1 (PP1) is a heterodimeric enzyme with serine/threonine phosphatase activity. It comprises a catalytic subunit and a targeting subunit or a specific protein inhibitor. The targeting subunit determines the enzyme localization, e.g., to glycogen particles (subunit G) or to myofibrils (subunit M).
Applicazioni
Protein Phosphatase-1 Catalytic Subunit, α-Isoform from rabbit has been used as a standard in protein phosphatase-1 inhibition assay.
Protein Phosphatase-1 Catalytic Subunit, α-Isoform from rabbit has been used in protein phosphatase reaction and in the digestion of adipocyte extracts.
Azioni biochim/fisiol
Protein phosphatase1 (PP1) is involved in glycogen metabolism and in regulation of muscle contractility. In addition, it is implicated in cell cycle and transcriptional regulation. Recombinant rabbit PP1α has properties in common with the native rabbit muscle protein including size, requirement for Mn2+ for activity, specificity for phosphorylase A, and inhibition by okadaic acid, microcystin LR, and phosphatase inhibitor2 (I-2).
Confezionamento
Package size based on protein content.
Definizione di unità
One unit will hydrolyze 1 nmole of p-nitrophenyl phosphate per min at pH 7.4 at 30 °C.
Stato fisico
Lyophilized powder containing imidazole buffer, pH 7.4, NaCl, DTT, EDTA, MnCl2, Tween 20, and trehalose as stabilizer.
Inibitore
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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I clienti hanno visto anche
Regulation of protein phosphatase-1
James B Aggen
Chemistry and Biology, 7.1, R13-R23 (2000)
Activity of membrane-associated sucrose synthase is regulated
by its phosphorylation status in cultured cells of sycamore (Acer
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by its phosphorylation status in cultured cells of sycamore (Acer
pseudoplatanus)
Javier P
Physiologia Plantarum (2004)
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.
T Hunter
Cell, 80(2), 225-236 (1995-01-27)
M C Faux et al.
Trends in biochemical sciences, 21(8), 312-315 (1996-08-01)
One important regulatory mechanism in the control of phosphorylation events is the subcellular location of phosphatases of kinases. Several serine/threonine phosphatases and kinases have now been shown to be associated with targeting subunits; these contribute to the organization and specificity
Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.
Parker GJ
The Journal of Biological Chemistry, 278(12), 10022-10027 (2003)
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