P7769
1,2-Diacyl-sn-glycero-3-phospho-L-serine
from bovine brain, ≥97% (TLC), amorphous powder, structural phospholipid
Sinonimo/i:
3-sn-Phosphatidyl-L-serine, L-α-Phosphatidyl-L-serine, PS, Phosphatidylserine
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
1,2-Diacyl-sn-glycero-3-phospho-L-serine, ≥97% (TLC), from bovine brain, amorphous powder
Origine biologica
bovine brain
Livello qualitativo
Saggio
≥97% (TLC)
Stato
amorphous powder
Temperatura di conservazione
−20°C
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Applicazioni
1,2-Diacyl-sn-glycero-3-phospho-L-serine has been used:
- as a lipid standard in time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectral fingerprints
- as a reference standard in thin layer chromatography (TLC) for quantifying lipids from astrocyte-conditioned media (ACM) treated fibroblasts
- as a component of large unilamellar vesicles for annexin A2 aggregation studies
Azioni biochim/fisiol
1,2-Diacyl-sn-glycero-3-phospho-L-serine or phosphatidylserine (PS) is a structurally diverse acidic phospholipid having fatty acid ester at the glycerol sn positions. Bovine brain cortex based PS is a potent brain nutrient. It favors neurotransmission and may improve memory in dementia. PS is also the major membrane phospholipid associated with the nuclear membrane, myelin, endoplasmic reticulum, Golgi and mitochondria. The synthesis of PS is catalyzed by phosphatidylserine synthase 1 from L-serine and CDP-diacylglycerol in the mitochondria-associated membrane (MAM) domains of the endoplasmic reticulum. PS is externalized during phagocytosis and is dysregulated in tumors making it a potential marker for therapeutic targeting.
A slowly metabolized structural phospholipid found mainly in gray matter.
Caratteristiche e vantaggi
This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Avvertenza
Solutions exposed to room temperature will decompose about 0.5% per day.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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