Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

P5057

Sigma-Aldrich

Paromomycin sulfate salt

powder, suitable for cell culture, BioReagent

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Formula empirica (notazione di Hill):
C23H45N5O14 · xH2SO4
Numero CAS:
Peso molecolare:
615.63 (free base basis)
Beilstein:
5715182
Codice UNSPSC:
12352207
ID PubChem:
NACRES:
NA.76

product name

Paromomycin sulfate salt, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg

Nome Commerciale

BioReagent

Livello qualitativo

Forma fisica

powder

Potenza

≥675 μg per mg

tecniche

cell culture | mammalian: suitable

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria

Modalità d’azione

protein synthesis | interferes

Stringa SMILE

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
OYJABWUHUYVDMJ-UDXJMMFXSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

Chemical structure: aminoglycoside
Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Applicazioni

  • Paromomycin sulfate salt has been used as a:
  • reference compound in antileishmanial activity
  • RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.
Recommended for use in cell culture applications at 100mg/L.
Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Azioni biochim/fisiol

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Altre note

1g,5g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Paromomycin
Davidson RN, et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(7), 653-660 (2009)
Use of a non-adherent cell culture system for testing the effect of 2,3'-dideoxyinosine against Cryptosporidium parvum
Lawton P, et al.
FEMS Microbiology Letters, 176(1), 235-240 (1999)
Jair L Siqueira-Neto et al.
PLoS neglected tropical diseases, 4(5), e675-e675 (2010-05-11)
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic side effects and prohibitive costs commonly incompatible with patients from the tropical endemic countries. In this sense, there is an urgent need for new drugs as a treatment
Nanoarchitectures for Neglected Tropical Protozoal Diseases: Challenges and State of the Art
Nano- and Microscale Drug Delivery Systems, 439-480 (2017)
Antiparasitic Agents
Infectious Diseases, 2, 1345-1372 (2017)

Articoli

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.