P4670

Propafenone hydrochloride

• Sinonimo/i: 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
• Formula empirica (notazione di Hill): C₂₁H₂₇NO₃ · HCl
• Numero CAS: 34183-22-7
• Peso molecolare: 377.90
• Numero CE: 251-867-9
• Numero MDL: MFCD00079243
• Codice UNSPSC: 41116107
• ID PubChem: 24278636
• NACRES: NA.77

Proprietà

• Stato: powder
• Livello qualitativo: 100
• Ideatore: Abbott
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
• InChI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H; XWIHRGFIPXWGEF-UHFFFAOYSA-N
• Informazioni sul gene: human ... ABCB1(5243) , ADRB1(153) , ADRB2(154) , ADRB3(155) , CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Descrizione

Descrizione generale

Propafenone hydrochloride is a calcium antagonist. It functions as a Na⁺ and K⁺ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

Applicazioni

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

Azioni biochim/fisiol

Blocks hKv1.5 and ATP-sensitive K⁺ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Caratteristiche e vantaggi

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3