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Merck
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Key Documents

Altri documenti

P0874

Sigma-Aldrich

Anti-Potassium Channel KIR6.1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinonimo/i:

Anti-KATP Inward Rectifier K+ Channel 4, Anti-KCNJ8

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About This Item

Numero MDL:
MFCD08705505
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

lyophilized powder

Reattività contro le specie

rat

tecniche

western blot: 1:200 using rat heart membranes

N° accesso UniProt

Q63664

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... KCNJ8(3764)
mouse ... Kcnj8(16523)
rat ... Kcnj8(25472)

Specificità

Specific for KIR6.1; does not cross react with KIR6.2.

Immunogeno

peptide, (C)KRNSMRRNNSMRRSN, corresponding to amino acid residues 382-396 of rat KIR6.1. This sequence has 15/16 residues identical in human, pig, rabbit, and mouse.

Stato fisico

Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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William C Cole et al.
Journal of cardiovascular electrophysiology, 14(1), 94-103 (2003-03-11)
ATP-sensitive potassium channels (K(ATP)) of vascular smooth muscle cells represent potential therapeutic targets for control of abnormal vascular contractility. The biophysical properties, regulation and pharmacology of these channels have received intense scrutiny during the past twenty years, however, the molecular
T Baukrowitz et al.
European journal of biochemistry, 267(19), 5842-5848 (2000-09-21)
The KATP channel is a heterooctamer composed of two different subunits, four inwardly rectifying K+ channel subunits, either Kir6. 1 or Kir6.2, and four sulfonylurea receptors (SUR), which belong to the family of ABC transporters. This unusual molecular architecture is
Mangala M Soundarapandian et al.
Journal of neurochemistry, 103(5), 1982-1988 (2007-09-22)
The Kir6.1 channels are a subtype of ATP-sensitive inwardly rectifying potassium (K(ATP)) channels that play an essential role in coupling the cell's metabolic events to electrical activity. In this study, we show that functional Kir6.1 channels are located at excitatory
Yang Yang et al.
The Journal of biological chemistry, 286(11), 9298-9307 (2011-01-11)
The vascular ATP-sensitive K(+) (K(ATP)) channel is targeted by a variety of vasoactive substances, playing an important role in vascular tone regulation. Our recent studies indicate that the vascular K(ATP) channel is inhibited in oxidative stress via S-glutathionylation. Here we
Maria Consiglia Trotta et al.
Frontiers in physiology, 9, 1475-1475 (2018-11-13)
The study explored the anti-hypertrophic effect of the melanocortin MC5R stimulation in H9c2 cardiac myocytes exposed to high glucose. This has been done by using α-MSH and selective MC5R agonists and assessing the expression of GLUT4 and GLUT1 transporters, miR-133

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