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P0275

Sigma-Aldrich

Poly(Glu, Tyr) sodium salt

greener alternative

Glu:Tyr (4:1), mol wt 20,000-50,000

Sinonimo/i:

L-Glutamic acid sodium salt (1:1) polymer with L-tyrosine

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About This Item

Numero CAS:
97105-00-5
Numero MDL:
MFCD00148022
Codice UNSPSC:
12352209
NACRES:
NA.26

Forma fisica

powder

Livello qualitativo

200

Rapporto d’alimentazione

Glu:Tyr (4:1)

PM

20,000-50,000

Punteggio alternativa più verde

old score: 48
new score: 45
Find out more about DOZN™ Scoring

Caratteristiche più verdi

Safer Solvents and Auxiliaries
Design for Energy Efficiency
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Colore

white to off-white

Categoria alternativa più verde

, Re-engineered

Temperatura di conservazione

−20°C

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Categorie correlate

Descrizione generale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, “Enhanced Energy Efficiency” and “Reduced Derivative”. Click here to view its DOZN scorecard.

Applicazioni

Poly(Glu, Tyr) sodium salt has been used as a substrate for
  • janus kinase 3 (JAK3) in enzyme linked immunosorbent assay (ELISA)-based assay
  • proto-oncogene tyrosine-protein kinase (Src) and zeta chain of T cell receptor associated protein kinase 70 (Zap70)
  • in in vitro tyrosine kinase assay

Azioni biochim/fisiol

Poly(glu, tyr) sodium salt is a polyamino acid with applications in cancer research.

Risultati analitici

Molecular weight based on viscosity. Also assayed by MALLS.

Altre note

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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A simple and robust automated kinase profiling platform using luminescent ADP accumulation technology
Larson B, et al.
Assay and Drug Development Technologies, 7(6), 573-584 (2009)
Jiaye Guo et al.
Biochemistry, 57(32), 4934-4951 (2018-07-06)
Human epidermal growth factor receptor 2 (HER2) is a validated breast cancer drug target for small molecule inhibitors that target the ATP-binding pocket of the kinase domain. In this work, a large-scale virtual screen was performed to a novel homology
Identification of Chinese Herbal Compounds with Potential as JAK3 Inhibitors
Su D, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM (2019)
Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation
Lecointre C, et al.
Structure, 26(4), 545-554 (2018)
C J Bruns et al.
Cancer research, 60(11), 2926-2935 (2000-06-13)
We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of a novel EGF-R tyrosine kinase inhibitor (PKI166) alone or in combination with gemcitabine (administered i.p.) can inhibit growth and metastasis of human pancreatic carcinoma

Articoli

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.