O7635

Anti-Osteopontin antibody produced in goat

affinity isolated antibody, lyophilized powder

• Sinonimo/i: Anti-OPN
• Numero MDL: MFCD02263865
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: goat
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: lyophilized powder
• Reattività contro le specie: mouse
• tecniche: capture ELISA: 0.2-0.8 μg/mL; immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections; neutralization: 1-3 μg/mL; western blot: 0.1-0.2 μg/mL
• N° accesso UniProt: P10923
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Spp1(20750)

Descrizione

Descrizione generale

The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.

Immunogeno

purified recombinant mouse osteopontin expressed in NSO cells.

Azioni biochim/fisiol

Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Risultati analitici

Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable