N8161
NS309
≥98% (HPLC), solid
Sinonimo/i:
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
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About This Item
Formula empirica (notazione di Hill):
C8H4Cl2N2O2
Numero CAS:
Peso molecolare:
231.04
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Saggio
≥98% (HPLC)
Stato
solid
Colore
yellow
Solubilità
DMSO: 22 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12
InChI
1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)
CVOUSAVHMDXCKG-UHFFFAOYSA-N
Azioni biochim/fisiol
NS309 is a Ca2+-activated IK/SK potassium channel activator.
Caratteristiche e vantaggi
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Avvertenza
air sensitive
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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Pedarzani, P., et al.
Abstr. Soc. Neurosci, 367-367 (2003)
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
Fan-Fan Li et al.
Placenta, 58, 9-16 (2017-10-01)
Excessive constriction of placental chorionic plate arteries (CPAs) may be associated with preeclampsia (PE). Nitric oxide (NO) as well as intermediate and small Ca The location of IK IK This study provides evidence that dysregulated IK
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null
Abbie C Johnson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2857-2869 (2016-11-07)
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high
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