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N5413

Sigma-Aldrich

Anti-Nestin antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-FJ21841, Anti-NES, Anti-Nbla00170

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About This Item

Numero MDL:
MFCD03455626
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen ~110 kDa (cleaved)
antigen ~177 kDa
antigen ~270 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

N° accesso UniProt

P48681

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... NES(10763)
mouse ... Nes(18008)
rat ... Nes(25491)

Descrizione generale

Nestin (NES) is a class VI cytoplasmic protein. It is expressed in the intermediate filaments and has a molecular weight of 177kDa. The gene encoding it is localized on human chromosome 1q23.1 with four exons.

Immunogeno

synthetic peptide corresponding to residues 254-270 of human Nestin. This sequence is 93% identical in rat.

Azioni biochim/fisiol

Nestin (NES) functions as a regulator of proteins which are involved in cell growth. It also interacts with other proteins of the intermediate filament. NES has been studied as a marker of neural stem cells.

Stato fisico

solution in phosphate buffered saline, containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
SLCK2368
SLCG0413
SLCC3419
SLBX5698
SLBT4572

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International journal of molecular medicine, 40(3), 814-824 (2017-07-18)
Pluripotent stem cells (PSCs) are regarded as potential sources that provide specific neural cells for cell therapy in some nervous system diseases. However, the mechanisms underlying the neural differentiation of PSCs remain largely unknown. MicroRNAs (miRNAs or miRs) are a class of
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Wei Zhao et al.
Scientific reports, 6, 21176-21176 (2016-02-18)
Restenosis or occlusion after vascular procedures is ascribed to intimal hyperplasia. Transforming growth factor (TGF)-β1 is involved in recruitment of mesenchymal stem cells (MSCs) following arterial injury, and its release from latent TGF-binding protein by matrix metalloproteinase (MMP)-14-induced proteolysis contributes
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Articoli

Neural Stem Cell FAQs

Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation.

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