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Sigma-Aldrich

NBQX disodium salt hydrate

≥98% (HPLC), lyophilized powder, neuroprotective AMPA/kainate glutamate receptor antagonist

Sinonimo/i:

1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate, FG 9202 disodium salt hydrate

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About This Item

Formula empirica (notazione di Hill):
C12H6N4Na2O6S · xH2O
Numero CAS:
118876-58-7
Peso molecolare:
380.24 (anhydrous basis)
Numero MDL:
MFCD12910445
Codice UNSPSC:
12352200
ID PubChem:
24277996
NACRES:
NA.77

product name

NBQX disodium salt hydrate, ≥98% (HPLC)

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

lyophilized powder

Condizioni di stoccaggio

desiccated

Colore

, brown to dark red-brown

Solubilità

H2O: >10 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

O.[Na+].[Na+].NS(=O)(=O)c1cccc2c1c(cc3nc([O-])c([O-])nc23)[N+]([O-])=O

InChI

1S/C12H8N4O6S.2Na.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;;1H2/q;2*+1;/p-2
LQSCHRKYVVVUFA-UHFFFAOYSA-L

Informazioni sul gene

human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901)

Applicazioni

NBQX disodium salt hydrate has been used:
  • in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
  • as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
  • in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)

Azioni biochim/fisiol

NBQX disodium salt hydrate is a neuroprotective AMPA/kainate glutamate receptor antagonist.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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