M9948
Mirin
≥98% (HPLC), powder
Sinonimo/i:
5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
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About This Item
Formula empirica (notazione di Hill):
C10H8N2O2S
Numero CAS:
Peso molecolare:
220.25
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Condizioni di stoccaggio
desiccated
Colore
red to orange
Solubilità
DMSO: >10 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
InChI
1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
YBHQCJILTOVLHD-YVMONPNESA-N
Informazioni sul gene
human ... MRE11A(4361)
Applicazioni
Mirin has been used:
- as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
- as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
- in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)
Azioni biochim/fisiol
Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.
Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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PLoS ONE, 8(10), e75406-e75406 (2013)
M Petroni et al.
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The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects
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