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Key Documents

M9808

Sigma-Aldrich

Anti-Muscarinic Acetylcholine Receptor (M1) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinonimo/i:

Acetylcholine Receptor antibody

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.43

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

lyophilized powder

Reattività contro le specie

mouse, rat

tecniche

immunoblotting: 1:200 using rat brain membranes
immunohistochemistry: suitable

N° accesso UniProt

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CHRM1(1128)
rat ... Chrm1(25229)

Descrizione generale

Muscarinic acetylcholine receptor 1 (M1) is a member of class A G protein-coupled receptors (GPCRs) family, which is encoded by the CHRM1 gene. Muscarinic receptors have seven transmembrane domains localized in the parasympathetic nerve sub-synaptic membrane. The CHRM1 gene is located on human chromosome location 11q12.3.
Muscarinic cholinergic receptor 1 (M1) is seen in the forebrain of rats.

Immunogeno

GST fusion protein of a part of the i3 intracellular loop of human M1 muscarinic acetylcholine receptor (mAChR) corresponding to amino acid residues 227-353.1, 2

Applicazioni

Anti-Muscarinic acetylcholine receptor (M1) antibody produced in rabbit has been used in immunohistochemistry and Western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Azioni biochim/fisiol

Muscarinic acetylcholine receptor 1 (M1) regulates normal prostate growth and reduced-level glandular secretion. Muscarinic receptors play a major role in tumor progression. Muscarinic acetylcholine receptors (mAChRs) regulates adenylyl cyclase and potassium channel activities. It also stimulates various mitogen-activated protein kinases. M1 may be useful for the discovery of therapeutics for Alzheimer′s disease.
Studies have shown that activation of muscarinic cholinergic receptor 1 (M1) in rats leads to changes in the endotoxin tolerance in the liver.

Stato fisico

Lyophilized from a solution of phosphate-buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Golnar Eftekhari et al.
European journal of pharmacology, 740, 436-441 (2014-07-11)
Endotoxin tolerance is a mechanism in which cells receiving low doses of endotoxin, enter a transient phase with less inflammatory response to the next endotoxin challenges. Central nervous system is known to modulate systemic inflammation through activation of the cholinergic
Anna Rebeka Oliveira Ferreira et al.
Frontiers in physiology, 13, 840179-840179 (2022-05-17)
Perturbations to nutrition during critical periods are associated with changes in embryonic, fetal or postnatal developmental patterns that may render the offspring more likely to develop cardiovascular disease in later life. The aim of this study was to evaluate whether
Jay F Muller et al.
The Journal of comparative neurology, 521(8), 1743-1759 (2013-04-06)
Muscarinic neurotransmission in the anterior basolateral amygdalar nucleus (BLa) mediated by the M1 receptor (M1R) is critical for memory consolidation. Although knowledge of the subcellular localization of M1R in the BLa would contribute to an understanding of cholinergic mechanisms involved
Sophie R Thomson et al.
Neuron, 95(3), 550-563 (2017-08-05)
Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu
xPharm: The Comprehensive Pharmacology Reference (2008)

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