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M8948

Sigma-Aldrich

Monoclonal Anti-Myocardin antibody produced in mouse

~2.0 mg/mL, clone MCR54, purified immunoglobulin

Sinonimo/i:

Anti-MYCD, Anti-MYOCD

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

MCR54, monoclonal

Stato

buffered aqueous solution

PM

antigen ~150 kDa

Reattività contro le specie

human

Confezionamento

antibody small pack of 25 μL

Concentrazione

~2.0 mg/mL

tecniche

western blot: 2.5-5 μg/mL using HEK-293T cells overexpressing myocardin

Isotipo

IgG2b

N° accesso UniProt

Q8IZQ8

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... MYOCD(93649)

Descrizione generale

Monoclonal Anti-Myocardin (mouse IgG2b isotype) is derived from the hybridoma MCR54 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human myocardin. Myocardin (MYOCD) is a transcriptional coactivator.
Myocardin (MYOCD) is expressed in the muscles and cardiomyocytes. It is a co-transcriptional factor.

Applicazioni

Monoclonal Anti-Myocardin antibody produced in mouse has been used in western blot analysisimmunofluorescence.

Azioni biochim/fisiol

Myocardin (MYOCD) takes part in the differentiation of vascular smooth muscle cells (VSMC). It is a co-factor of serum response factor (SRF) and regulates the activation of those genes which are dependent on SRF. MYOCD forms a complex with SRF on DNA.
Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It regulates the expression of a set of cardiac and smooth muscle-specific genes. Myocardin was implicated in the pathogenesis of atherosclerosis, Alzheimer′s disease, and malignant transformation.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

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Certificati d'analisi (COA)

Lot/Batch Number
020M4772

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The serum response factor coactivator myocardin is required for vascular smooth muscle development
Li S, et al.
Proceedings of the National Academy of Sciences of the USA, 100(16), 9366-9370 (2003)
Fibroblast growth factor 12 is a novel regulator of vascular smooth muscle cell plasticity and fate
Song SH, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 36(9), 1928-1936 (2016)
Myocardin in biology and disease
Miano JM
Journal of biomedical research, 29(1), 3-3 (2015)
Amarnath Talasila et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(10), 2355-2365 (2013-07-05)
Myocardin, a potent transcriptional coactivator of serum response factor, is involved in vascular development and promotes a contractile smooth muscle phenotype. Myocardin levels are reduced during vascular injury, in association with phenotypic switching of smooth muscle cells (SMCs). However, the
Linda Raphel et al.
PloS one, 7(8), e44052-e44052 (2012-09-01)
Myocardin is thought to have a key role in smooth muscle cell (SMC) development by acting on CArG-dependent genes. However, it is unclear whether myocardin-induced SMC maturation and increases in agonist-induced calcium signalling are also associated with increases in the
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