M7945

Mephetyl tetrazole

≥98% (HPLC), oil

• Sinonimo/i: 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
• Formula empirica (notazione di Hill): C₂₀H₂₂N₄O
• Numero CAS: 916923-10-9
• Peso molecolare: 334.41
• Numero MDL: MFCD11045297
• Codice UNSPSC: 12352200
• ID PubChem: 329818044
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: oil
• Colore: pale yellow
• Solubilità: DMSO: >5 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
• InChI: 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3; VREPWWBWXVLSEF-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Mephetyl tetrazole is a potent and selective K_v1.5 potassium channel blocker.

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)