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M6045

Sigma-Aldrich

2-Methyl-4-isothiazolin-3-one hydrochloride

≥99%

Sinonimo/i:

MIT hydrochloride, Methylisothiazolinone hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C4H5NOS · HCl
Numero CAS:
26172-54-3
Peso molecolare:
151.61
Beilstein:
3993054
Numero CE:
247-499-3
Numero MDL:
MFCD06804636
Codice UNSPSC:
51102829
ID PubChem:
24897073
NACRES:
NA.76

Saggio

≥99%

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl[H].CN1SC=CC1=O

InChI

1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
SJXPQSRCFCPWQQ-UHFFFAOYSA-N

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Descrizione generale

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a derivative of the synthetic isothiazolinone.

Applicazioni

Methylisothiazolinone (MIT HCl) has been used:


  • as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
  • to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Azioni biochim/fisiol

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT HCl is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

Avvertenze

Danger

Indicazioni di pericolo

H301,H314,H317,H410

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1

Rischi supp

EUH071

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000080173
0000080172
029M4866V
108M4889V
019M4847V

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Sigma-Aldrich

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Sigma-Aldrich

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Supelco

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Benzisothiazolinone-15N 98 atom % 15N, 95% (CP)

Sigma-Aldrich

687677

Benzisothiazolinone-15N

Zhenzhen Wang et al.
Biomaterials, 113, 145-157 (2016-11-07)
As common reactive oxygen species, H2O2 is widely used for bacterial inactivation and wound disinfection. However, the concentrations used are always higher than physiological levels, which frequently result in potential toxicity to healthy tissue and even delay wound healing. Here
Siamak Javanbakht et al.
Materials science & engineering. C, Materials for biological applications, 96, 302-309 (2019-01-05)
In compression with the intravenous administration, oral delivery most commonly used due to the non-invasive nature and the fact that avoids patient pain and discomfort. By consideration this aim, ibuprofen as a model drug was loaded into two-dimensional tunnels and
Christina L Burnett et al.
International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22)
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble
Shen Du et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17), 7408-7416 (2002-08-28)
Neurodegenerative disorders in humans may be triggered or exacerbated by exposure to occupational or environmental agents. Here, we show that a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons but not
Zhengxi Wei et al.
Toxicology letters, 338, 67-77 (2020-12-09)
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic
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