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Key Documents

PHR1597

Supelco

CMIT/MIT

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

5-chloro-2-methyl-2h-isothiazolin-3-one/2-methyl-2h-isothiazol-3-one

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About This Item

Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

300

Famiglia di API

cmit/mit

Forma fisica

liquid

CdA

current certificate can be downloaded

Confezionamento

ampule of 1 mL

applicazioni

pharmaceutical (small molecule)

Temperatura di conservazione

2-30°C

Descrizione generale

Pharmaceutical secondary standard for applications in quality control, provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
CMIT/MIT is an isothiazolone biocide having a 3:1 ratio of CMIT and MIT, widely used for its broad-spectrum action against microbes, algae, and fungi. It is one of the active ingredients of humidifier disinfectants and a commonly used preservative in industrial products such as cosmetics, paints, adhesives and detergents.

Applicazioni

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H317,H319,H412

Classi di pericolo

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
LRAC6520
LRAB7781
LRAB0761
LRAA4713

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Supelco

32053

Bronopol

ProClin™ 300 pkg of 50 mL, ProClin™ preservative for use in IVD manufacturing, CMIT/MIT 3 %

Sigma-Aldrich

48912-U

ProClin™ 300

The mechanism of action of isothiazolone biocides
Williams TM
PowerPlant Chemistry, 9(1), 14-14 (2007)
Refined exposure assessment for three active ingredients of humidifier disinfectants
Lee JH, et al.
Environmental Engineering Research, 18(4), 253-257 (2013)
Fatal misuse of humidifier disinfectants in Korea: importance of screening risk assessment and implications for management of chemicals in consumer products
Lee JH, et al.
PowerPlant Chemistry, 9(1), 14-14 (2012)
Risk Assessment of 5-Chloro-2-Methylisothiazol-3 (2H)-One/2-Methylisothiazol-3 (2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics
Kim MK, et al.
Toxicological Research, 35(2), 103-103 (2019)
CMIT/MIT induce apoptosis and inflammation in alveolar epithelial cells through p38/JNK/ERK1/2 signaling pathway
Lee J, et al.
Molecular & Cellular Toxicology, 15(1), 41-48 (2019)

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