M4074

Mometasone furoate

≥98% (HPLC)

• Sinonimo/i: (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• Formula empirica (notazione di Hill): C₂₇H₃₀Cl₂O₆
• Numero CAS: 83919-23-7
• Peso molecolare: 521.43
• Numero MDL: MFCD00866003
• Codice UNSPSC: 51111800
• ID PubChem: 329817988
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Attività ottica: [α]/D +50 to +60°, c = 0.5 in methanol
• Colore: white to off-white
• Solubilità: DMSO: ≥20 mg/mL
• Ideatore: Schering Plough
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl
• InChI: 1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1; WOFMFGQZHJDGCX-ZULDAHANSA-N
• Informazioni sul gene: human ... NR3C1(2908)

Descrizione

Applicazioni

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.

Azioni biochim/fisiol

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis. In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.

Mometasone furoate is an anti-inflammatory glucocorticoid.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H360D
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable