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M4008

Sigma-Aldrich

Morin hydrate

powder

Sinonimo/i:

2′,3,4′,5,7-Pentahydroxyflavone

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About This Item

Formula empirica (notazione di Hill):
C15H10O7 · xH2O
Numero CAS:
654055-01-3
Peso molecolare:
302.24 (anhydrous basis)
Numero CE:
207-542-9
Numero MDL:
MFCD00217054
Codice UNSPSC:
12171500
ID PubChem:
24278552
NACRES:
NA.77

Forma fisica

powder

Livello qualitativo

100

Colore

yellow

Solubilità

methanol: 50 mg/mL

Stringa SMILE

O.Oc1ccc(c(O)c1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2
MYUBTSPIIFYCIU-UHFFFAOYSA-N

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Applicazioni

Morin hydrate has been used:
  • to investigate its antitumor functionality using cell viability and apoptosis assay in human cancer cell lines.
  • as a fluorescence stain to detect aluminum in motor neurons and lumbar cord.
  • to study its protective effect on neuronal hearing loss and on neural stem cells (NSCs) proliferation and differentiation

Azioni biochim/fisiol

Morin hydrate is a flavonoid with antioxidant properties. It has been shown to protect cells against oxygen radical damage. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase, a free-radical generating enzyme. At concentrations of 75-100 micromolar, morin inhibits oxidation of low density lipoprotein (LDL) by free radicals or Cu2+. Morin has been reported to inhibit rat brain phospha­tidyl­inositol­phos­phate kinase activity in vitro and in vivo.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Morin hydrate promotes inner ear neural stem cell survival and differentiation and protects cochlea against neuronal hearing loss
He Q, et al.
Journal of Cellular and Molecular Medicine, 21(3), 600-608 (2017)
C H Cheng
Life sciences, 61(20), 2035-2047 (1997-01-01)
Phosphatidylinositol-4,5-bisphosphate occupies a central role in signal transduction and in cellular transformation. Phosphatidylinositol-4,5-bisphosphate is produced by the enzymatic phosphorylation of phosphatidylinositol-4-phosphate by phosphatidylinositolphosphate kinase (EC 2.7.1.68). Inhibition of this enzyme might conceivably lowers the cellular pool of phosphatidylinositol-4,5-bisphosphate, thus constituting
T W Wu et al.
Life sciences, 57(3), PL51-PL56 (1995-01-01)
Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at
L H Zeng et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 75(6), 717-720 (1997-01-01)
Oxygen-derived free radicals are known to injure the endothelium of aorta in diverse disorders. In this study we compared the cytoprotective effects of three flavonoids against oxyradical damage to porcine aortic endothelial cells in vitro. Cultured porcine aortic endothelial cells
L H Zeng et al.
Life sciences, 55(18), PL351-PL357 (1994-01-01)
Cultured rat glomerular mesangial cells were damaged when exposed to oxyradicals generated either from xanthine oxidase plus hypoxanthine, or by superoxide radicals formed from menadione. Morin hydrate is an antioxidant extracted from yellow Brazil wood. When morin hydrate was added
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Articoli

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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