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M3536

Sigma-Aldrich

Mycophenolic acid

powder, suitable for cell culture, BioReagent

Sinonimo/i:

6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid, NSC 129185

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About This Item

Formula empirica (notazione di Hill):
C17H20O6
Numero CAS:
24280-93-1
Peso molecolare:
320.34
Beilstein:
1295848
Numero CE:
246-119-3
Numero MDL:
MFCD00036814
Codice UNSPSC:
12352207
ID PubChem:
24896854
NACRES:
NA.76

Nome del prodotto

Mycophenolic acid, powder, BioReagent, suitable for cell culture

Origine biologica

Penicillium brevicompactum

Livello qualitativo

300

Nome Commerciale

BioReagent

Stato

powder

tecniche

cell culture | mammalian: suitable

Colore

white to yellow-white

Punto di fusione

<143.0 °C

Solubilità

methanol: 50 mg/mL

Modalità d’azione

enzyme | inhibits

Temperatura di conservazione

2-8°C

Stringa SMILE

COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
HPNSFSBZBAHARI-RUDMXATFSA-N

Informazioni sul gene

human ... IMPDH1(3614) , IMPDH2(3615)

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Categorie correlate

Applicazioni

Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.

Azioni biochim/fisiol

Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.

Avvertenza

As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

Nota sulla preparazione

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

Avvertenze

Danger

Indicazioni di pericolo

H302,H341,H360D,H372,H410

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

Organi bersaglio

Immune system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
049M4044V
019M4082V
093M4080V
067M4053V
086M4046V

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Sigma-Aldrich

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USP

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Supelco

PHR1451

Mycophenolate Mofetil

FK-506 monohydrate &#8805;98% (HPLC)

Sigma-Aldrich

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FK-506 monohydrate

N-Boc-3-aminothiophene 96%

Sigma-Aldrich

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Hypoxanthine &#8805;99.0%

Sigma-Aldrich

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Wei Li et al.
Nature microbiology, 7(6), 882-895 (2022-05-11)
Apicomplexan parasites, such as Toxoplasma gondii, have specific adaptations that enable invasion and exit from the host cell. Owing to the phylogenetic distance between apicomplexan parasites and model organisms, comparative genomics has limited capacity to infer gene functions. Further, although
Chia-Chun Chang et al.
Cellular and molecular life sciences : CMLS, 79(8), 420-420 (2022-07-15)
The cytoophidium is a unique type of membraneless compartment comprising of filamentous protein polymers. Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step of de novo GTP biosynthesis and plays critical roles in active cell metabolism. However, the molecular regulation of
Carlo Yague-Sanz et al.
Genes & development, 34(13-14), 883-897 (2020-06-06)
Transcription by RNA polymerase II (RNAPII) is a dynamic process with frequent variations in the elongation rate. However, the physiological relevance of variations in RNAPII elongation kinetics has remained unclear. Here we show in yeast that a RNAPII mutant that
Burkhard Tönshoff et al.
Transplantation reviews (Orlando, Fla.), 25(2), 78-89 (2011-04-02)
Mycophenolate mofetil (MMF) is widely used for maintenance immunosuppressive therapy in pediatric renal and heart transplant recipients. Children undergo developmental changes (ontogeny) of drug disposition, which may affect drug metabolism of the active compound mycophenolic acid (MPA). Therefore, a detailed
Hylke de Jonge et al.
Therapeutic drug monitoring, 31(4), 416-435 (2009-06-19)
Although therapeutic drug monitoring (TDM) of immunosuppressive drugs has been an integral part of routine clinical practice in solid organ transplantation for many years, ongoing research in the field of immunosuppressive drug metabolism, pharmacokinetics, pharmacogenetics, pharmacodynamics, and clinical TDM keeps
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