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M3199

Sigma-Aldrich

MK-212 hydrochloride

≥98% (HPLC)

Sinonimo/i:

2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732

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About This Item

Formula empirica (notazione di Hill):
C8H11ClN4·HCl
Numero CAS:
61655-58-1
Peso molecolare:
235.11
Numero CE:
262-883-0
Numero MDL:
MFCD00673963
Codice UNSPSC:
12352200
ID PubChem:
329817966
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

white to off-white

Solubilità

DMSO: ≥20 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.Clc1cncc(n1)N2CCNCC2

InChI

1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H
PFIZGLUIYAZQFU-UHFFFAOYSA-N

Azioni biochim/fisiol

Selective 5-HT2C serotonin receptor agonist.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Martilias Farrell et al.
Psychopharmacology, 211(2), 149-159 (2010-06-08)
The extended ternary complex theory of receptor function states a ligand can be classified as an inverse agonist, agonist, or neutral antagonist based on its ability to preferentially stabilize the inactive conformation, the active conformation, or to have no preference
Peter Salchner et al.
Psychopharmacology, 185(3), 282-288 (2006-03-08)
We have recently reported that acute treatment with the selective serotonin reuptake inhibitor fluoxetine exacerbates escape responses to airjet and facilitates airjet-induced activation of locus coeruleus (LC) neurons. Here we aimed to identify the 5-HT receptor subtype(s) mediating the anxiogenic-like
E G Kuznetsova et al.
Bulletin of experimental biology and medicine, 142(5), 594-597 (2007-04-07)
A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of
N K Popova et al.
Neuroscience and behavioral physiology, 40(4), 357-361 (2010-03-26)
The functional activity of serotonin 5-HT(2A) and 5-HT(2C) receptors and the expression of the genes encoding them were studied in Norway rats bred for 60 generations for the presence and absence of high levels of stress-evoked aggression to humans. There
Adriane M dela Cruz et al.
Behavioural pharmacology, 20(8), 720-730 (2009-11-11)
Only a subgroup of human drug users progress from initial drug taking to drug addiction. The learned associations between the effects of the drug and the environment in which it is experienced is an important aspect of the progression to
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