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Merck
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M157

Sigma-Aldrich

MEN-10,376

≥95% (HPLC), solid

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Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C57H68N12O10
Numero CAS:
135306-85-3
Peso molecolare:
1081.22
Numero MDL:
MFCD00144736
Codice UNSPSC:
51111800
ID PubChem:
24896670
NACRES:
NA.32

Livello qualitativo

200

Saggio

≥95% (HPLC)

Stato

solid

Colore

white

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O

InChI

1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)
QQHOFZNACVKNHK-UHFFFAOYSA-N

Informazioni sul gene

human ... TACR2(6865)

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Amino Acid Sequence

Asp-Tyr-Trp-Val-Trp-Trp-Lys-NH2

Azioni biochim/fisiol

Potent and selective NK-2 tachykinin receptor antagonist.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
SLBC6472V
041M1696V
041M1696
069K1725
074K11452

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O Löfgren et al.
Burns : journal of the International Society for Burn Injuries, 25(2), 125-129 (1999-04-20)
Recent studies have proposed that activation of the sensory nervous system after thermal injury induces the release of vasoactive neuropeptides, including tachykinins which contribute to the local inflammatory reaction as well as to the nociceptive transmission at the spinal cord
B Bianchi et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 12(1), 6-10 (1999-04-03)
Radioligand binding experiments were performed with crude homogenates from normal human skin in order to investigate substance P receptor density. Binding of [3H]substance P ([3H]SP) reached equilibrium after 20 min and was saturable analysis of saturation curves gave a significantly
Koichi Tan-No et al.
Brain research, 952(1), 7-14 (2002-10-05)
Intrathecal (i.t.) administration of big dynorphin (1-10 fmol), a prodynorphin-derived peptide consisting of dynorphin A and dynorphin B, to mice produced a characteristic behavioral response, the biting and/or licking of the hindpaw and the tail along with slight hindlimb scratching
William G Paterson et al.
Gut, 56(10), 1347-1352 (2007-05-26)
Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the pathophysiology of oesophageal pain syndromes and hiatus hernia formation. The aim of the current study was to
Donatella Mutolo et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 295(1), R243-R251 (2008-05-16)
We have previously shown that ionotropic glutamate receptors in the caudal portion of the nucleus tractus solitarii (NTS), especially in the commissural NTS, play a prominent role in the mediation of tracheobronchial cough and that substance P potentiates this reflex.
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