M1523

Muscimol

≥98% (TLC), powder, GABAA receptor agonist.

• Sinonimo/i: 3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
• Formula empirica (notazione di Hill): C₄H₆N₂O₂
• Numero CAS: 2763-96-4
• Peso molecolare: 114.10
• Beilstein: 1618960
• Numero CE: 220-430-4
• Numero MDL: MFCD00057894
• Codice UNSPSC: 12352200
• ID PubChem: 24896662
• NACRES: NA.77

Proprietà

• product name: Muscimol, powder
• Forma fisica: powder
• Livello qualitativo: 200
• Colore: white to off-white
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: NCC1=CC(=O)NO1
• InChI: 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7); ZJQHPWUVQPJPQT-UHFFFAOYSA-N
• Informazioni sul gene: rat ... Gabra2(29706)

Descrizione

Descrizione generale

Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.

Applicazioni

Muscimol has been used:

• to reduce conditioned fear-expression in lateral amygdala (LA)
• to eliminate cortical cell response in ferrets
• to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches

Azioni biochim/fisiol

GABA_A receptor agonist.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300,H336
• Consigli di prudenza: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Classi di pericolo: Acute Tox. 2 Oral - STOT SE 3
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges